We had occasion to drive across Ohio the last couple of days headed to West Virginia—just being a tourist. It’s what we do!
If any of you are planning the route between Dayton and Charleston, WV, I recommend US 35. It is an excellent route for any size vehicle. It is a four-lane highway for most of the way. About 20 miles from Chillicothe, OH (headed East), it goes down to a two lane (but still a good road). Then you get on I-64 and it is typical Interstate.
This is a good route and I recommend it.